I took the baseline model I developed for my “How to Win Your Bracket Pool” article and created a “high-volatility” version to produce bracket simulations so I could look for teams that are uniquely capable of making unexpected runs in this year’s tournament. I compared the results of these simulations to currently available Vegas futures on the two primary sports betting websites (DraftKings & FanDuel) to look for high leverage opportunities in the high risk/high reward space.

I identified seven such opportunities (in alphabetical order):

• Alabama advancing to the Elite 8 (+120 on DraftKings)
• Colorado State advancing to the Sweet 16 (+400 on DraftKings)
• Iowa State advancing to the Elite 8 (+220 on DraftKings)
• Kansas advancing to the Sweet 16 (+240 on FanDuel)
• Tennessee advancing to the Elite 8 (+120 on FanDuel)
• Texas Tech advancing to the Elite 8 (+180 on FanDuel)
• VCU advancing to the Sweet 16 (+370 on FanDuel)

Before you begin reading this article, I want to make one thing abundantly clear: I’m not telling you how to fill out the perfect bracket; that’s impossible (insert cliché about the astronomically small odds of this ever happening). Rather, I’m giving you statistically sound, pragmatic advice on how to win your bracket pool between you and your friends (and the spoils that come along with it). If you follow these foolproof steps, you should finish at (or at the very least near) the top:

Step 1: Advance all 1 and 2 seeds to the Sweet 16.

Okay, I know, this is super chalky and people may rag on you for making this move. Furthermore, the odds are heavily against all eight 1 and 2 seeds advancing to the Sweet 16. However, picking which 1 or 2 seed is going to get upset is a fool’s gambit. You put yourself at risk of losing easy points that your opponents will gain. You’re better off taking a couple small gambles in other early round games, and just playing it safe here.

To further drive home my point, consider this – in the last five tournaments, 30 of the 40 teams (75%) on the 1 and 2 seed line advanced to the Sweet 16. If you can essentially lock in 6 correct teams in your predicted Sweet 16, you should do it.

Step 2: Advance all 3 seeds to the second round.

The same chalkiness mentioned in step 1 definitely applies here as well, but the same logic applies as well. The difference here is that a lower seed upset over a 3 in the second round is much more likely in comparison to a similar 1 or 2 upset. Thus, auto-advancing the 3 seeds should only apply to the first round. It’s fun bragging about being the one person who accurately picked the crazy 14 over 3 upset, but you know what’s more fun? Bragging about winning your bracket pool.

In a similar fashion to step 1, I really want to drive home this point as well. In the last three tournaments, only one 14 over 3 upset has occurred, and it was a 4-point victory by Oakland over Kentucky in 2024.

Step 3: Use the following statistical data to fill out the rest of your bracket.
(*Note*: The 0% values listed do not imply that the result cannot happen. Rather, the result is extremely unlikely [less than 0.1% likelihood])

In years past, I had developed a predictive model to attempt to project who has the best chance of advancing far into the tournament. I refined the model to further optimize the predictive results, then normalized the projections for each region to create a probability of advancing in any given round for every team in the tournament. I used historic tournament results from games that took place between 2010 to 2017.

As part of an update from 2019, I moved to a model that predicts the exact score of each game. After the projected score is developed, the model turns that into a projected probability of victory, then uses rules of conditional probability to project teams advancing in the tournament. I also updated the training data for the model to include tournament results from games that took place between 2014 and 2023.

South Region

East Region

Midwest Region

West Region

Bonus TL;DR version: Synthesizing the above charts for people who don’t like numbers.

Most Likely First Round Upsets

Going crazy picking a ton of upsets doesn’t do you any good. Instead, I would pick one (or two tops if you’re feeling real wild) from the following options:

Most Likely 13/4 Upsets

• (13) Yale over (4) Texas A&M – 27.4%
• (13) High Point over (4) Purdue- 25.0%

Most Likely 12/5 Upsets

• (12) Colorado State over (5) Memphis – 56.1%
• (12) UC San Diego over (5) Michigan – 45.6%

Most Likely 11/6 Upsets

• (11) North Carolina over (6) Ole Miss – 46.9%
• (11) VCU over (6) BYU – 43.7%

Toss-Up Games

These are the 7/10 and 8/9 games that could get either way. The goal here is to get 5+ out of 8 correct. I recommend the following strategy:

• (8) Louisville vs. (9) Creighton – Flip a coin.
• (7) Marquette vs. (10) New Mexico – Take Marquette.
• (8) Mississippi State vs. (9) Baylor – Flip a coin.
• (7) Saint Mary’s vs. (10) Vanderbilt – Take Saint Mary’s.
• (8) Gonzaga vs. (9) Georgia – Take Gonzaga.
• (7) UCLA vs. (10) Utah State – Take UCLA.
• (8) Connecticut vs. (9) Oklahoma – Take Connecticut.
• (7) Kansas vs. (10) Arkansas – Take Kansas.

Best Final Four Picks by Region

SOUTH

Chalk – (1) Auburn

Value Pick – (3) Iowa State, (2) Michigan State

Dark Horse – N/A (No good value)

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EAST

Chalk – (1) Duke

Value Picks – (2) Alabama, (3) Wisconsin

Dark Horse – (4) Arizona

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MIDWEST

Chalk – (1) Houston

Value Pick – (2) Tennessee

Dark Horse – (8) Gonzaga, (6) Illinois

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WEST

Chalk – (1) Florida

Value Pick – (3) Texas Tech

Dark Horse – (4) Maryland

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Most Likely Champions

• (1) Duke (25.6%)
• (1) Auburn (15.5%)
• (1) Florida (15.2%)
• (1) Houston (15.1%)
• (2) Alabama (5.9%)
• (2) Tennessee (5.4%)